DSM-IV Criteria for

Psychoactive Substance

Dependence

1. Self-Control…

-Substance taken in larger amounts than intended

-Unsuccessful efforts to cut down

-Excessive time spent acquiring, consuming, or recovering from drug

2. Social/Occupational Functioning...

-Social/occupational activities missed due to drug use

-Associated social, psychological, or physical problems

3. Tolerance & Withdrawal

-Marked tolerance

-Withdrawal

-tremors, nausea, anxiety, etc.

-substance taken to relieve/avoid withdrawal

DSM-IV Criteria for

Psychoactive Substance

Abuse

1. Maladaptive pattern of substance use

-substance-related failure to fulfill major role

obligations

-continued use despite social or physical

problems associated with drug use

-recurrent use despite obvious hazards

(e.g., driving drunk)

-recurrent substance-related legal problems

2. Symptoms have persisted for at least 1

month

 

 

Depressants

Alcohol

-Stimulates GABA System

Acute Effects

-Stimulation à Depression

-Reduction of tension

-Cognitive impairment

-Diminished sexual performance

-Lack of motor coordination

-Emotional labiality

Long-term

-tolerance

-Cirrhosis

-Korsakoff's Psychosis

-withdrawal

-Delirium Tremens

-death

-Fetal Alcohol Syndrome

Barbiturates

-stimulate GABA system

Acute effects: similar to alcohol

Long term effects: particularly dangerous withdrawal

Opiates

-poppy

-opium

-morphine

-heroin

-opioid receptors (enkaphelins & endorphins)

-methods of ingestion

Acute Effects

-relaxation

-euphoria

-loss of pain/worries

Withdrawal

-Flu-like symptoms

-cramps

-nausea

-chills

-increased blood pressure and heart rate

 

 

 

 

 

Stimulants

Nicotine

-Tobacco plant

-Methods of ingestion

-Nicotinic Receptors

Acute Effects

-Stimulation

-Relaxation

Long-term effects

-withdrawal

-Lung disease

-Heart disease

-Low birth weight babies

-second hand smoke

 

 

 

 

 

 

 

Cocaine and Amphetamines

-prevents reuptake of DA

-methods of ingestion

Acute effects

-increased performance

-indefatigability

-increased self-confidence

-paranoia

-drug induced psychosis

Long term effects

-tolerance and withdrawal

-personality change

-paranoia

-impaired sleeping and eating

-birth defects

 

 

 

 

 

 

 

Hallucinogens

Marijuana (Cannibis)

-Hemp Plant

-Delta-9-TCH

-Methods of ingestion

Acute Effects

-relaxation and sociability

-increased appetite

-dry mouth

-emotional labiality

-fragmented thoughts and cognitive impairment

-paranoia

-hallucinations

-motor impairment

Long Term Effects

-amotivational syndrome

-lung disease

LSD, Psilocybin, Mescaline, MDMA

-Effect serotonin system

-History of hallucinogens

Acute effects

-expansive mood

-synesthesia

-hallucinations

-bad trips

Long term effects

-flashbacks

-long term brain damage??

 

 

Theories of Substance Dependence

1. Addictive Personality

Personality characterized by proneness to addiction

2. Behavioral

Tension reduction

Solomon's Opponent Process Theory

Siegel's Theory of Counterconditioning

3. Physiological

Genetics of Alcoholism

Biochemistry

 

Solomon's Opponent-Process Theory

Drug US (e.g., alcohol) elicits...

1. a-process (UR1)

-fast acting

-remains for duration of stimulus

-corresponds to drug "high"

2. b-process (UR2)

-slow to respond

-long-lasting

-opposite of a-process

With repeated US stimulation...

1. b-process becomes faster & stronger

2. a-process is unaffected

Siegel's Counterconditioning Theory

1. Components:

A. US (alcohol) --> UR (intoxication)

B. CS (bar)

2. Conditioning:

A. Pairing of CS & US

B. CS eventually elicits CR (as usual)

3. What's unusual?

For many drugs, direction of CR is opposite

to that of the UR (e.g., withdrawal)

-possibly triggering b-process?

Genetics of Alcoholism

Increased rates of alcoholism in family members

54% concordance rate in MZ vs 28% concordance in DZ twins

Adoption studies show increased rate of problem drinking in adoptees whose biological parents were alcoholics

May be the ability to tolerate the effects of alcohol

-low rates of alcoholism in populations unable to metabolize alcohol

-self-report of low level of intoxication and less body sway predicted development of alcohol abuse 10 years later in men

 

 

 

 

 

Alcoholic Subtypes

Cloninger et al. (1988)

1. Type I

-found in males and females

-anxious personality traits

-dependence on anti-anxiety effects of alcohol

-age of onset after 25

-adult onset problem drinking in bio parents and exposure to alcohol in adoptive home

-less severe

-drink to reduce tension

2. Type II

-only found in males

-antisocial personality traits

-alcohol abuse in bio parents

-dependence on euphoriant effects of alcohol

-age of onset before 25

-drink to increase pleasure

Treatment for Substance Dependence

1. Alcoholics Anonymous Model

-Alcoholism is a disease

-Advocate abstinence

-12 step program

-Religious focus

-Strong focus on support

2. Psychological

-Aversion Therapy

-Broad-Spectrum Behavioral Treatment

-Self-monitoring of drinking

-Self-selection of goals

-Altering beliefs

-Coping strategies for high-risk situations

-Abstinence vs. Controlled Drinking

Predictors of controlled drinking

-severity of alcoholism

-belief in necessity of abstinence

-gender (female is better)

-age (young is better)

 

 

3. Pharmacological

-Deterrent drugs (e.g., Antabuse)

-Replacement drugs (e.g., Methadone)

-Antagonist drugs (e.g., Naltrexone)

4.Prevention programs

-self-esteem enhancement (no so effective)

-social skills training

-resistance training