DSM-IV Criteria for
Psychoactive Substance
Dependence
1. Self-Control…
-Substance taken in larger amounts than intended
-Unsuccessful efforts to cut down
-Excessive time spent acquiring, consuming, or recovering from drug
2. Social/Occupational Functioning...
-Social/occupational activities missed due to drug use
-Associated social, psychological, or physical problems
3. Tolerance & Withdrawal
-Marked tolerance
-Withdrawal
-tremors, nausea, anxiety, etc.
-substance taken to relieve/avoid withdrawal
DSM-IV Criteria for
Psychoactive Substance
Abuse
1. Maladaptive pattern of substance use
-substance-related failure to fulfill major role
obligations
-continued use despite social or physical
problems associated with drug use
-recurrent use despite obvious hazards
(e.g., driving drunk)
-recurrent substance-related legal problems
2. Symptoms have persisted for at least 1
month
Depressants
Alcohol
-Stimulates GABA System
Acute Effects
-Stimulation à Depression
-Reduction of tension
-Cognitive impairment
-Diminished sexual performance
-Lack of motor coordination
-Emotional labiality
Long-term
-tolerance
-Cirrhosis
-Korsakoff's Psychosis
-withdrawal
-Delirium Tremens
-death
-Fetal Alcohol Syndrome
Barbiturates
-stimulate GABA system
Acute effects: similar to alcohol
Long term effects: particularly dangerous withdrawal
Opiates
-poppy
-opium
-morphine
-heroin
-opioid receptors (enkaphelins & endorphins)
-methods of ingestion
Acute Effects
-relaxation
-euphoria
-loss of pain/worries
Withdrawal
-Flu-like symptoms
-cramps
-nausea
-chills
-increased blood pressure and heart rate
Stimulants
Nicotine
-
Tobacco plant-Methods of ingestion
-Nicotinic Receptors
Acute Effects
-Stimulation
-Relaxation
Long-term effects
-withdrawal
-Lung disease
-Heart disease
-Low birth weight babies
-
second hand smoke
Cocaine and Amphetamines
-prevents reuptake of DA
-methods of ingestion
Acute effects
-increased performance
-indefatigability
-increased self-confidence
-paranoia
-drug induced psychosis
Long term effects
-tolerance and withdrawal
-personality change
-paranoia
-impaired sleeping and eating
-birth defects
Hallucinogens
Marijuana (Cannibis)
-
Hemp Plant-Delta-9-TCH
-Methods of ingestion
Acute Effects
-relaxation and sociability
-increased appetite
-dry mouth
-emotional labiality
-fragmented thoughts and cognitive impairment
-paranoia
-hallucinations
-motor impairment
Long Term Effects
-amotivational syndrome
-lung disease
LSD, Psilocybin, Mescaline, MDMA
-
Effect serotonin system-History of hallucinogens
Acute effects
-expansive mood
-synesthesia
-hallucinations
-bad trips
Long term effects
-flashbacks
-long term brain damage??
Theories of Substance Dependence
1. Addictive Personality
Personality characterized by proneness to addiction
2. Behavioral
Tension reduction
Solomon's Opponent Process Theory
Siegel's Theory of Counterconditioning
3. Physiological
Genetics of Alcoholism
Biochemistry
Solomon's Opponent-Process Theory
Drug US (e.g., alcohol) elicits...
1. a-process (UR
1)-fast acting
-remains for duration of stimulus
-corresponds to drug "high"
2. b-process (UR
2)-slow to respond
-long-lasting
-opposite of a-process
With repeated US stimulation...
1. b-process becomes faster & stronger
2. a-process is unaffected
Siegel's Counterconditioning Theory
1. Components:
A. US (alcohol) --> UR (intoxication)
B. CS (bar)
2. Conditioning:
A. Pairing of CS & US
B. CS eventually elicits CR (as usual)
3. What's unusual?
For many drugs, direction of CR is opposite
to that of the UR (e.g., withdrawal)
-possibly triggering b-process?
Genetics of Alcoholism
Increased rates of alcoholism in family members
54% concordance rate in MZ vs 28% concordance in DZ twins
Adoption studies show increased rate of problem drinking in adoptees whose biological parents were alcoholics
May be the ability to tolerate the effects of alcohol
-low rates of alcoholism in populations unable to metabolize alcohol
-self-report of low level of intoxication and less body sway predicted development of alcohol abuse 10 years later in men
Alcoholic Subtypes
Cloninger et al. (1988)
1. Type I
-found in males and females
-anxious personality traits
-dependence on anti-anxiety effects of alcohol
-age of onset after 25
-adult onset problem drinking in bio parents and exposure to alcohol in adoptive home
-less severe
-drink to reduce tension
2. Type II
-only found in males
-antisocial personality traits
-alcohol abuse in bio parents
-dependence on euphoriant effects of alcohol
-age of onset before 25
-drink to increase pleasure
Treatment for Substance Dependence
1. Alcoholics Anonymous Model
-Alcoholism is a disease
-Advocate abstinence
-12 step program
-Religious focus
-Strong focus on support
2. Psychological
-Aversion Therapy
-Broad-Spectrum Behavioral Treatment
-Self-monitoring of drinking
-Self-selection of goals
-Altering beliefs
-Coping strategies for high-risk situations
-Abstinence vs. Controlled Drinking
Predictors of controlled drinking
-severity of alcoholism
-belief in necessity of abstinence
-gender (female is better)
-age (young is better)
3. Pharmacological
-Deterrent drugs (e.g., Antabuse)
-Replacement drugs (e.g., Methadone)
-Antagonist drugs (e.g., Naltrexone)
4.Prevention programs
-self-esteem enhancement (no so effective)
-social skills training
-resistance training